Notodoris serenae is found in Western Central Pacific and the Philippines. Characterized by its colour pattern, ranging in colour from dull white to grey-green with scattered raised black spots. The most characteristic difference is the development of 3 long extrabranchial appendages which shield the three distinct gills. Some specimens have a yellowish margin of the foot.
The species in this genus feed exclusively on calcareous sponge Leucetta chagosensis.